She is a female porn star who works for Hector at Hector's Place along Peter Street in Soho. She is a playable character in Free Roaming mode, and is unlocked after the player has collected a total of 24 key rings.
She is mainly seen in Mission 16, This Geezer, Hector, when Eddie O'Connor goes to visit Hector to find out the whereabouts of Hector's boss, Jimmer Collins. Madame Celina is based at Hector's Place in the centre of Soho, down Peter Street. At Hector's Place, she participates in the "Blue movies" (pornography) that they make there, which is used to make money for the Collins crew. Madame Celina is one of the female porn stars of the movies. This business however is trashed when Eddie comes looking for Hector. In Eddie's pursuit to stop Hector, members of the Collins crew at Hector's Place attempt to stop him and a shootout erupts which results in many deaths. After confronting Hector, Eddie then leaves the area. Before he leaves however, he has the option to kill Madame Celina, if she hasn't been killed prior to Eddie confronting Hector. Killing Madame Celina or not killing her will not effect the games' storyline in any way. In the following mission, Jimmer Collins, you can return to Hector's Place and find Madame Celina or her dead body depending on what choice was made. Leo, a male colleague of Madame Celina's, can be found inside Hector's Place as well and can also be killed by Eddie.
- Madame Celina is a playable character in the Special Feature, Free Roaming. She is unlocked once a total of 24 key rings have been collected during the missions.
- She is the only female character that has the voice of a man. If Eddie grabs her from behind and tries to break her neck, she will say something in the voice of man.
- In Free Roaming, Madame Celina starts off down Peter Street outside Hector's Place in Soho.
- When playing as Madame Celina, she is unable to engage in combat or use weapons like all female playable characters in the game.